First National Tour
Cristy Candler has replaced Stefanie Brown as Nessarose.
Pamela Shandrow has replaced Melanie Field as a member of the ensemble and an understudy for Madame Morrible.
Second National Tour
Marilyn Caskey has replaced Jody Gelb as Madame Morrible.
Timothy Britten Parker replaced Martin Moran as Doctor Dillamond.
Stephanie Torns has replaced Christine Dwyer as the standby for Elphaba.
KJ Hippensteel has replaced Daniel Torres in the ensemble and as an understudy for Fiyero.